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Does Garcinia Cambogia Actually Work. Woman Smiling and Holding a Supplement I managed to find several research studies on Garcinia Cambogia, in both animals and humans. According to some studies in rats, it can inhibit a fat producing enzyme called Citrate Lyase, making it more difficult for the body to produce fat out of carbohydrates (1). Other rat studies show increased levels of the neurotransmitter serotonin. This could theoretically lead to reduced appetite and cravings (2).